Langerhans cell activation in diabetic small fiber polyneuropathy
نویسندگان
چکیده
A 63-year-old man with type 2 diabetes developed painful feet with touch allodynia. Skin biopsy revealed prominent Langerhans cells (LC) staining with the standard epidermal nerve fiber antibody PGP9.5 when compared to a normal control (figure). Fiber density was severely decreased at the leg (mean 0.2 fibers/ mm, 95% confidence interval [CI] 0.1–0.4) and thigh (mean 2.2 fibers/mm, 95% CI 1.8–2.8). These findings were consistent with small fiber neuropathy. LC are reported to be increased in the skin with diabetes, small fiber polyneuropathy, and mechanical allodynia. They are dendritic cells with S-100 antibody positivity and are important in antigen presentation. With denervation, PGP9.5 is upregulated within LC, but their exact role in small fiber pathogenesis is not understood.
منابع مشابه
Pronounced reduction of cutaneous Langerhans cell density in recently diagnosed type 2 diabetes.
Immune-mediated processes have been implicated in the pathogenesis of diabetic polyneuropathy. Langerhans cells (LCs) are the sole dendritic cell type located in the healthy epidermis and exert tolerogenic immune functions. We aimed to determine whether alterations in cutaneous LC density and intraepidermal nerve fiber density (IENFD) are present in patients with recently diagnosed type 2 diabe...
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